A Case of Pent phi gus Vulgaris Showing Reactivity with Pentphigus Antigens ( Dsgl and Dsg 3 ) and Desntocollins
نویسندگان
چکیده
Both petnphigus vulgaris antigen (PVA; Dsg3) and petnphigus foliaceus antigen (PFA; Dsgl) are tnembers of the destnoglein subfamily of the cadherin supergene fatnily. Another destnosotnal cadherin, destnocollin, is occasionally recognized by certain petnphigus sera. We present a 38-year-old Japanese tnale who showed clinically and histopathologically typical features of petnphigus vulgaris, whose sera reacted with all PVA, PFA, and destnocollins using itntnunoblotting of both hutnan epidertnis and bovine snout epidertnis. Studies using dotnain-specific fusion proteins of PFA and PVA suggested that this patient's serutn reacted with the intracellular dOlnain
منابع مشابه
Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions.
Pemphigus is an autoimmune disease of skin adhesion associated with autoantibodies against a number of keratinocyte antigens, such as the adhesion molecules desmoglein (Dsg) 1 and 3 and acetylcholine receptors. The notion that anti-Dsg antibodies alone are responsible for blisters in patients with pemphigus vulgaris (PV) stems from the ability of rDsg1 and rDsg3 to absorb antibodies that cause ...
متن کاملMultiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus.
Patients with pemphigus vulgaris (PV) harbor antibodies reactive against self-antigens expressed at the surface of keratinocytes, primarily desmoglein (Dsg) 3 and, to a lesser extent, Dsg1. Conventionally, only antibodies targeting these molecules have been thought to contribute to disease pathogenesis. This notion has been challenged by a growing pool of evidence that suggests that antibodies ...
متن کاملSalivary Desmoglein Enzyme-Linked Immunosorbent Assay for Diagnosis of Pemphigus Vulgaris: A Noninvasive Alternative Test to Serum Assessment
BACKGROUND Serum desmoglein enzyme-linked immunosorbent assay (ELISA) is used for the diagnosis and monitoring of pemphigus diseases. OBJECTIVES To compare the diagnostic accuracy of salivary antidesmoglein (Dsg) 1 and 3 ELISA in the diagnosis of pemphigus vulgaris (PV) patients with that of serum desmogleins ELISA. METHODS Eighty-six untreated PV patients and 180 age- and sex-matched PV-fr...
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متن کاملResidues and Dissipation Kinetics of Two Imidacloprid Nanoformulations on Bean (Phaseolus vulgaris L.) under Field Conditions
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